Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis

Autoimmun Rev. 2007 Nov;7(1):65-70. doi: 10.1016/j.autrev.2007.08.001. Epub 2007 Aug 30.

Abstract

Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis, Experimental / immunology*
  • Arthritis, Experimental / physiopathology
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / physiopathology
  • Autoantibodies / blood*
  • Autoantigens / immunology*
  • Autoimmunity
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Cartilage / physiopathology
  • Collagen Type II / immunology*
  • Collagen Type II / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Disease Models, Animal
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Osteoclasts / physiology
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism

Substances

  • Autoantibodies
  • Autoantigens
  • Collagen Type II
  • Cytokines
  • Inflammation Mediators