WOMBAT: a tool for mixed model analyses in quantitative genetics by restricted maximum likelihood (REML)

J Zhejiang Univ Sci B. 2007 Nov;8(11):815-21. doi: 10.1631/jzus.2007.B0815.

Abstract

WOMBAT is a software package for quantitative genetic analyses of continuous traits, fitting a linear, mixed model; estimates of covariance components and the resulting genetic parameters are obtained by restricted maximum likelihood. A wide range of models, comprising numerous traits, multiple fixed and random effects, selected genetic covariance structures, random regression models and reduced rank estimation are accommodated. WOMBAT employs up-to-date numerical and computational methods. Together with the use of efficient compilers, this generates fast executable programs, suitable for large scale analyses. Use of WOMBAT is illustrated for a bivariate analysis. The package consists of the executable program, available for LINUX and WINDOWS environments, manual and a set of worked example, and can be downloaded free of charge from (http://agbu. une.edu.au/~kmeyer/wombat.html).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Likelihood Functions*
  • Mice
  • Models, Genetic*
  • Software*