Abstract
Hematopoietic stem cells give rise to multiple lineages of cells. This process is governed by a tightly controlled signaling network regulated by cytokines and a direct cell-cell contact. Notch signaling represents one of the major pathways activated during direct interaction between hematopoietic progenitor cells and bone marrow stroma. A critical role of Notch signaling in differentiation of T- and B-lymphocytes has now been established. Until recently, the role of Notch signaling in the development of myeloid cells and particular dendritic cells remained unclear. In this review, we discuss recent exciting findings that shed light on the critical role of Notch in differentiation and the function of dendritic cells and its impact on immune responses.
MeSH terms
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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Bone Marrow / immunology
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Cell Differentiation* / immunology
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Dendritic Cells / cytology*
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / immunology
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Hematopoietic Stem Cells / metabolism
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Humans
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Lymphocyte Activation
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Mice
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NF-kappa B / immunology
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NF-kappa B / metabolism
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Receptors, Notch / immunology*
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Receptors, Notch / metabolism
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Signal Transduction*
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T-Lymphocytes, Regulatory / cytology
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / metabolism
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Th1 Cells / cytology
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Th1 Cells / immunology
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Th1 Cells / metabolism
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Th2 Cells / cytology
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Th2 Cells / immunology
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Th2 Cells / metabolism
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Transcriptional Activation
Substances
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NF-kappa B
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Receptors, Notch