Enantioselective Henry reaction catalyzed by a C2-symmetric bis(oxazoline)-Cu(OAc)2.H2O complex

Sandeep K Ginotra; Vinod K Singh

doi:10.1039/b714153j

Enantioselective Henry reaction catalyzed by a C2-symmetric bis(oxazoline)-Cu(OAc)2.H2O complex

Org Biomol Chem. 2007 Dec 21;5(24):3932-7. doi: 10.1039/b714153j. Epub 2007 Oct 29.

Authors

Sandeep K Ginotra¹, Vinod K Singh

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Kanpur, India 208 016.

PMID: 18043796
DOI: 10.1039/b714153j

Abstract

A C(2)-symmetric diethyl (i)Pr-bis(oxazoline)-Cu(OAc)(2).H(2)O was found to be an efficient catalyst for catalyzing an enantioselective Henry reaction between nitromethane and various aldehydes to provide beta-hydroxy nitroalkanes with high chemical yields (up to 95%) and enantiomeric excesses (up to 97%).