Abstract
Four compounds, apicidin (1), N-methylharman (2), cylo (Phe-Tyr) (3) and indole-3-acetic acid (4) were isolated from the mangrove endophytic fungus ZZF42 from the South China Sea. Their structures were elucidated by spectral data. Compound 1 was first isolated from the marine fungus. Compound 2 was firstly isolated from marine microorganism. Compound 1 exhibited selective in vitro cytotoxicity towards KB ahd KBv200 with IC50 values of less than 0.78 microg/ml.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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China
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Fungi / chemistry*
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Fungi / metabolism
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Humans
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Indoleacetic Acids / chemistry
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Indoleacetic Acids / isolation & purification
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Indoleacetic Acids / pharmacology
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Nasopharyngeal Neoplasms / pathology
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Rhizophoraceae / microbiology*
Substances
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Alkaloids
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Antineoplastic Agents
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Indoleacetic Acids
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Peptides, Cyclic
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apicidin
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indoleacetic acid