Abstract
Purpose:
To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART).
Design:
Interventional case report.
Methods:
Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART.
Results:
Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year.
Conclusions:
Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
MeSH terms
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AIDS-Related Opportunistic Infections / drug therapy*
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AIDS-Related Opportunistic Infections / physiopathology
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AIDS-Related Opportunistic Infections / virology
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Acyclovir / analogs & derivatives
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Acyclovir / therapeutic use
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Adult
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Antiretroviral Therapy, Highly Active*
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Antiviral Agents / therapeutic use*
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CD4 Lymphocyte Count
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Disease Progression
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Drug Therapy, Combination
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Female
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Foscarnet / therapeutic use
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Ganciclovir / therapeutic use
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Herpes Zoster Ophthalmicus / drug therapy*
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Herpes Zoster Ophthalmicus / physiopathology
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Herpes Zoster Ophthalmicus / virology
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Herpesvirus 3, Human / genetics
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Herpesvirus 3, Human / isolation & purification*
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Humans
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Polymerase Chain Reaction
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RNA, Viral / analysis
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Retinal Necrosis Syndrome, Acute / drug therapy*
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Retinal Necrosis Syndrome, Acute / physiopathology
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Retinal Necrosis Syndrome, Acute / virology
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Valacyclovir
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Valine / analogs & derivatives
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Valine / therapeutic use
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Vision, Ocular / physiology*
Substances
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Antiviral Agents
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RNA, Viral
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Foscarnet
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Valine
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Valacyclovir
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Ganciclovir
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Acyclovir