Abstract
Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antifungal Agents / pharmacology*
-
Candida glabrata / drug effects*
-
Candida glabrata / enzymology
-
Candida glabrata / metabolism
-
Caspofungin
-
Chitin / metabolism*
-
Drug Resistance, Fungal*
-
Echinocandins / pharmacology*
-
Fungal Proteins / genetics
-
Fungal Proteins / metabolism
-
Lipopeptides
-
Microbial Sensitivity Tests
-
Mitogen-Activated Protein Kinases / genetics
-
Mitogen-Activated Protein Kinases / metabolism*
-
Up-Regulation
Substances
-
Antifungal Agents
-
Echinocandins
-
Fungal Proteins
-
Lipopeptides
-
Chitin
-
Mitogen-Activated Protein Kinases
-
Caspofungin