Monster protein controls calcium entry and fights infection

Amy N Radermacher; Gerald R Crabtree

doi:10.1016/j.immuni.2007.12.009

Monster protein controls calcium entry and fights infection

Immunity. 2008 Jan;28(1):13-4. doi: 10.1016/j.immuni.2007.12.009.

Authors

Amy N Radermacher¹, Gerald R Crabtree

Affiliation

¹ Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA.

PMID: 18199413
DOI: 10.1016/j.immuni.2007.12.009

Abstract

Sustained calcium signaling in T cells is critical for development and activation. In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection.

Publication types

Comment

MeSH terms

Animals
Calcium Signaling / immunology*
Leishmaniasis / immunology*
Membrane Proteins / metabolism*
Neoplasm Proteins / metabolism*
Signal Transduction / immunology
T-Lymphocytes / immunology
T-Lymphocytes / metabolism*
T-Lymphocytes / microbiology

Substances

Ahnak protein, mouse
Membrane Proteins
Neoplasm Proteins