Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp. (Tree1-7)

J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):133-7. doi: 10.1080/10286020701273783.

Abstract

The metatrophic fungus Paecilomyces sp. (Tree1-7) was isolated from an estuarine mangrove from the Taiwan Strait. The methanol extract of the fungal mycelium exhibited cytotoxicity against hepG2. Paeciloxanthone (1), a new xanthone, and the known compounds emodin (2) and chrysophanol (3), were isolated from the extract. Their structures were elucidated by spectroscopic experiments. Paeciloxanthone (1) exhibited in vitro cytotoxicity against hepG2 (IC(50)=1.08 microg/mL), acetylcholineesterase (AChE) inhibitory (IC(50)=2.25 microg/mL) and antimicrobial activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Molecular Structure
  • Paecilomyces / chemistry*
  • Xanthones / chemistry*
  • Xanthones / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Xanthones
  • paeciloxanthone