Abstract
The first phytochemical investigation of Scabiosa hymettia led to the isolation and characterization of nine known compounds, 2-10, and of the new kaempferol derivative 1. In total, two flavonoids, three coumarins, three iridoids, and two phenolic constituents were obtained. The chemosystematic value of these compounds, as well as the metabolic relationship between swertiamarin (6) and the other isolated coumarins, are discussed. Both the extracts as well as all isolated constituents of S. hymettia were evaluated for their antimicrobial activities against six Gram-positive or Gram-negative bacteria, and against three human pathogenic fungi. The new compound 1 was found to exhibit the highest activity against all organisms tested.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Dipsacaceae / chemistry*
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Flavonoids / chemistry*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Fungi / drug effects
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Iridoids / chemistry*
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Kaempferols / chemistry*
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Kaempferols / isolation & purification
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Kaempferols / pharmacology
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Magnetic Resonance Spectroscopy / methods
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Magnetic Resonance Spectroscopy / standards
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Microbial Sensitivity Tests
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Molecular Structure
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Reference Standards
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Coumarins
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Flavonoids
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Glucosides
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Iridoids
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Kaempferols
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kaempferol 3-O-(3-O-acetyl-6-O-(E)-p-coumaroyl)-b-d-glucopyranoside