Aurocitrin and related polyketide metabolites from the wood-decay fungus Hypocrea sp. BCC 14122

J Nat Prod. 2008 May;71(5):902-4. doi: 10.1021/np700740a. Epub 2008 Apr 2.

Abstract

The known gentisaldehyde antibiotic aurocitrin (1), its cis-olefinic isomer (2), a salicylaldehyde analogue (3), two new benzofuran derivatives (4 and 5), and a new dihydroisocoumarin (6) were isolated from the wood-decay fungus Hypocrea sp. BCC 14122. The structures were elucidated primarily by NMR and mass spectroscopic analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Aldehydes / isolation & purification*
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology
  • Candida albicans / drug effects
  • Chlorocebus aethiops
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Hypocrea / chemistry*
  • KB Cells
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Nuclear Magnetic Resonance, Biomolecular
  • Plasmodium falciparum / drug effects
  • Staphylococcus aureus / drug effects
  • Stereoisomerism
  • Vero Cells
  • Wood / microbiology

Substances

  • Aldehydes
  • Antimalarials
  • Antineoplastic Agents
  • Benzofurans
  • Coumarins
  • aurocitrin