Two new lignan glucosides from the fruit of Vitex cannabifolia

J Nat Med. 2008 Jan;62(1):47-51. doi: 10.1007/s11418-007-0184-1. Epub 2007 Jul 28.

Abstract

Two new phenyldihydronaphthalene-type lignan glucosides, vitecannasides A (1) and B (2) were isolated from the fruit of Vitex cannabifolia Sieb. et. Zucc. (Verbenaceae) along with the six known lignan derivatives (3-8), four known iridoid glucosides (9-12), three known flavonoids (13-15), and one known phenylbutanone glucoside (16). Their chemical structures were determined on the basis of spectroscopic data as well as chemical evidence. The scavenging effect of 1, 2, and 11-16 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was examined. Compounds 1, 2, 14, and 15 exhibited stronger activity than that of L: -cysteine. Especially, 14 and 15 showed more potent activity than that of alpha-tocopherol.

Publication types

  • Comparative Study

MeSH terms

  • Biphenyl Compounds
  • Cysteine / chemistry
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification*
  • Fruit
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Iridoids / chemistry
  • Iridoids / isolation & purification*
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Picrates / chemistry
  • Vitex / chemistry*
  • alpha-Tocopherol / chemistry

Substances

  • Biphenyl Compounds
  • Flavonoids
  • Free Radical Scavengers
  • Glucosides
  • Iridoids
  • Lignans
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl
  • alpha-Tocopherol
  • Cysteine