Abstract
Tea preparations from the herb Artemisia annua L. (Aa) which is used in traditional Chinese medicine might offer an inexpensive way of producing artemisinin drugs locally. We compared Aa with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in semi-immune adults. After seven days, the cure rate was 7/10 for the Aa compared to 7/9 for SP; this dropped to 4/10 for Aa and 4/9 for SP at day 14 and to 1/9 for Aa and 3/8 for SP at day 28.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Antimalarials / therapeutic use*
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Artemisia annua*
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Double-Blind Method
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Drug Combinations
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Drugs, Chinese Herbal / therapeutic use*
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Female
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Humans
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Male
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Parasitemia / drug therapy
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Parasitemia / parasitology
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Phytotherapy / methods
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Plasmodium falciparum / drug effects
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Pyrimethamine / therapeutic use*
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Sulfadoxine / therapeutic use*
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Tanzania
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Treatment Outcome
Substances
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Antimalarials
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Drug Combinations
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Drugs, Chinese Herbal
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fanasil, pyrimethamine drug combination
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Sulfadoxine
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Pyrimethamine