Abstract
Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amino Acid Sequence / genetics
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Animals
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Chromatin / genetics
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Chromatin / metabolism*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Epigenesis, Genetic / genetics*
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Gene Expression Regulation, Fungal / genetics
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Histone-Lysine N-Methyltransferase
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Histones / chemistry
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Histones / genetics
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Histones / metabolism*
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Humans
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Lysine / metabolism*
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Macromolecular Substances / metabolism
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Methylation
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Protein Processing, Post-Translational / genetics*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Chromatin
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DNA-Binding Proteins
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Histones
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Macromolecular Substances
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Histone-Lysine N-Methyltransferase
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SET1 protein, S cerevisiae
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Lysine