Epithelial-mesenchymal transition and the stem cell phenotype

Cell Stem Cell. 2008 Jun 5;2(6):511-2. doi: 10.1016/j.stem.2008.05.007.

Abstract

Epithelial-mesenchymal transition (EMT) is a developmental process in which epithelial cells acquire the motile, migratory properties of mesenchymal cells. In a recent issue of Cell, Mani et al. (2008) show that induction of EMT stimulates cultured breast cells to adopt characteristics of stem cells.

Publication types

  • Introductory Journal Article
  • Comment

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Breast Neoplasms / pathology
  • CD24 Antigen / metabolism
  • Cell Movement
  • Cell Transdifferentiation*
  • Cell Transformation, Neoplastic
  • Epithelial Cells / cytology*
  • Female
  • Humans
  • Hyaluronan Receptors / metabolism
  • Mesenchymal Stem Cells / cytology*
  • Mesoderm / cytology
  • Mesoderm / physiology
  • Neoplasm Invasiveness
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology*
  • Tumor Cells, Cultured

Substances

  • Biomarkers, Tumor
  • CD24 Antigen
  • Hyaluronan Receptors