Abstract
After mice received orogastric administration of a fluoroquinolone-resistant Klebsiella pneumoniae strain, subcutaneous treatment with ciprofloxacin, levofloxacin, and moxifloxacin promoted persistent low-density colonization in 10% to 40% of the mice, whereas treatment with clindamycin consistently promoted high-density colonization. No emergence of fluoroquinolone-resistant gram-negative bacilli was detected in the mice during or after treatment with the fluoroquinolone antimicrobial agents.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Animals
-
Anti-Bacterial Agents* / pharmacology
-
Anti-Bacterial Agents* / therapeutic use
-
Clindamycin / therapeutic use
-
Drug Resistance, Bacterial*
-
Fluoroquinolones* / pharmacology
-
Fluoroquinolones* / therapeutic use
-
Gram-Negative Bacteria / drug effects*
-
Intestines / microbiology*
-
Klebsiella pneumoniae / drug effects*
-
Klebsiella pneumoniae / growth & development
-
Mice
-
Microbial Sensitivity Tests
Substances
-
Anti-Bacterial Agents
-
Fluoroquinolones
-
Clindamycin