Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

Eur J Pharmacol. 2008 Sep 4;591(1-3):293-9. doi: 10.1016/j.ejphar.2008.06.074. Epub 2008 Jun 27.

Abstract

Schisandrin is the main active ingredient isolated from the fruit of Schisandra chinensis Baill. Recent studies have demonstrated that schisandrin exhibits anti-oxidative effects in vivo. In the present study, the effect of schisandrin on plasma nitrite concentration in lipopolysaccharide (LPS)-treated mice was evaluated. It also significantly inhibited carrageenan-induced paw edema and acetic acid-induced vascular permeability in mice. Furthermore, schisandrin had a protective effect on lipopolysaccharide (LPS)-induced sepsis. In vitro, our results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-kappaB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Capillary Permeability / drug effects
  • Cell Line
  • Cyclooctanes / isolation & purification
  • Cyclooctanes / pharmacology*
  • Cyclooxygenase 2 / drug effects
  • Cyclooxygenase 2 / metabolism
  • Dinoprostone / antagonists & inhibitors
  • Dinoprostone / metabolism
  • Fruit
  • Gene Expression Regulation / drug effects
  • Inflammation / drug therapy*
  • Inflammation / etiology
  • Inflammation / physiopathology
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Lipopolysaccharides
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Male
  • Mice
  • Mice, Inbred ICR
  • Nitric Oxide / antagonists & inhibitors
  • Nitric Oxide / biosynthesis
  • Nitric Oxide Synthase Type II / drug effects
  • Nitric Oxide Synthase Type II / metabolism
  • Nitrites / blood
  • Polycyclic Compounds / isolation & purification
  • Polycyclic Compounds / pharmacology*
  • Schisandra / chemistry*
  • Sepsis / prevention & control

Substances

  • Anti-Inflammatory Agents
  • Cyclooctanes
  • Lignans
  • Lipopolysaccharides
  • Nitrites
  • Polycyclic Compounds
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Cyclooxygenase 2
  • schizandrin
  • Dinoprostone