Abstract
Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.
MeSH terms
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Angiogenesis Inhibitors / pharmacology
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Animals
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / metabolism*
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Humans
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Integrins / metabolism*
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Neovascularization, Physiologic* / drug effects
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Pericytes / metabolism
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Receptors, Collagen / metabolism
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Receptors, Fibronectin / metabolism
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Receptors, Laminin / metabolism
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Receptors, Vitronectin / metabolism
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Signal Transduction* / drug effects
Substances
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Angiogenesis Inhibitors
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Integrins
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Receptors, Collagen
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Receptors, Fibronectin
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Receptors, Laminin
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Receptors, Vitronectin