Abstract
The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.
MeSH terms
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Acylation
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Aminoglycosides / chemical synthesis*
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Anti-Bacterial Agents / chemical synthesis*
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Bacterial Proteins / metabolism
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Butirosin Sulfate / chemical synthesis
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Butirosin Sulfate / pharmacology
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Indicators and Reagents
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Membrane Transport Proteins / metabolism
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Transaminases / metabolism
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Proteins
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ButB protein, Bacillus circulans
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Indicators and Reagents
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Membrane Transport Proteins
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Butirosin Sulfate
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BtrR aminotransferase, Bacillus circulans
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Transaminases