The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne

Christos C Zouboulis; Silke Schagen; Theodosios Alestas

doi:10.1007/s00403-008-0879-5

The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne

Arch Dermatol Res. 2008 Sep;300(8):397-413. doi: 10.1007/s00403-008-0879-5. Epub 2008 Aug 9.

Authors

Christos C Zouboulis¹, Silke Schagen, Theodosios Alestas

Affiliation

¹ Department of Dermatology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de

PMID: 18690467
DOI: 10.1007/s00403-008-0879-5

Abstract

Acne is the most common skin disease which affects millions of people worldwide. Seborrhea and sebostasis are major cosmetic problems but also lead occasionally to diseases. This article summarizes the data of newest research of sebostasis, seborrhoea and acne made possible through the development of human and animal sebocyte culture models.

Publication types

Review

MeSH terms

Acne Vulgaris / physiopathology*
Cells, Cultured
Corticotropin-Releasing Hormone / physiology
Dermatitis, Seborrheic / physiopathology*
Fatty Acids / biosynthesis
Female
Humans
Inflammation / etiology
Lipogenesis
Male
Peroxisome Proliferator-Activated Receptors / physiology
Receptors, Cell Surface / physiology
Sebaceous Glands / cytology*
Sebaceous Glands / drug effects
Sebaceous Glands / physiopathology*
Sebum / physiology*

Substances

Fatty Acids
Peroxisome Proliferator-Activated Receptors
Receptors, Cell Surface
Corticotropin-Releasing Hormone