Abstract
A new biflavanone, 2,2'',3,3''-tetrahydrorobustaflavone 7,4',7''-trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4',7''-trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D- and 2D-NMR experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Biflavonoids / isolation & purification*
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Biflavonoids / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Selaginellaceae / chemistry*
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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2,2'',3,3''-tetrahydrorobustaflavone 7,4',7''-trimethyl ether
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Antineoplastic Agents, Phytogenic
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Biflavonoids