The microRNA-200 family regulates epithelial to mesenchymal transition

Emily L Paterson; Natasha Kolesnikoff; Philip A Gregory; Andrew G Bert; Yeesim Khew-Goodall; Gregory J Goodall

doi:10.1100/tsw.2008.115

The microRNA-200 family regulates epithelial to mesenchymal transition

ScientificWorldJournal. 2008 Sep 21:8:901-4. doi: 10.1100/tsw.2008.115.

Authors

Emily L Paterson¹, Natasha Kolesnikoff, Philip A Gregory, Andrew G Bert, Yeesim Khew-Goodall, Gregory J Goodall

Affiliation

¹ Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia. emily.paterson@imvs.sa.gov.au

Abstract

Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.

MeSH terms

Animals
Cell Line
Dogs
Epithelium / physiology
Homeodomain Proteins / physiology
Humans
Mesoderm / physiology
MicroRNAs / physiology*
Neoplasm Metastasis / physiopathology
Neoplasms / etiology*
Nerve Tissue Proteins / physiology
RNA-Binding Proteins / physiology
Transcription Factors / physiology
Zinc Finger E-box-Binding Homeobox 1

Substances

GEMIN2 protein, human
Homeodomain Proteins
MicroRNAs
Nerve Tissue Proteins
RNA-Binding Proteins
Transcription Factors
ZEB1 protein, human
Zinc Finger E-box-Binding Homeobox 1