Regulation of vitamin D homeostasis: implications for the immune system

Evelyne van Etten; Katinka Stoffels; Conny Gysemans; Chantal Mathieu; Lut Overbergh

doi:10.1111/j.1753-4887.2008.00096.x

Regulation of vitamin D homeostasis: implications for the immune system

Nutr Rev. 2008 Oct;66(10 Suppl 2):S125-34. doi: 10.1111/j.1753-4887.2008.00096.x.

Authors

Evelyne van Etten¹, Katinka Stoffels, Conny Gysemans, Chantal Mathieu, Lut Overbergh

Affiliation

¹ The Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Katholieke Universiteit Leuven , Leuven, Belgium.

PMID: 18844839
DOI: 10.1111/j.1753-4887.2008.00096.x

Abstract

Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism*
Calcitriol / metabolism
Endocrine System / physiology*
Humans
Immunity, Cellular / drug effects*
Immunity, Cellular / physiology
Receptors, Calcitriol / metabolism
Receptors, Calcitriol / physiology*
Vitamin D* / analogs & derivatives
Vitamin D* / immunology
Vitamin D* / physiology

Substances

Receptors, Calcitriol
Vitamin D
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Calcitriol