Abstract
Staphylococcal spp. are notorious for causing biofilm-related device-associated infections, leading to tens of thousands of deaths per year. In this paper, we review quorum sensing inhibitors as potential therapeutics for even the most persistent infections. The animal models reviewed are subcutaneous graft, central venous catheter (CVC), ureteral stent and wound models, and a wound case study. The therapeutic approaches reviewed are the use of RNAIII inhibiting peptide (RIP) and its non-peptide analog. These have been shown to prevent or treat infections caused by any staphylococcal strain tested, including antibiotic-resistant strains like CA-MRSA USA300.
MeSH terms
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Animals
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Anti-Infective Agents / pharmacology*
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Biofilms / drug effects*
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Biofilms / growth & development
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Catheter-Related Infections / drug therapy*
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Catheter-Related Infections / microbiology
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Catheter-Related Infections / physiopathology
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Catheters, Indwelling / adverse effects
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Disease Models, Animal
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Drug Resistance, Bacterial
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Gallic Acid / analogs & derivatives
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Gallic Acid / pharmacology
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Hexoses / pharmacology
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Prosthesis-Related Infections / physiopathology
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Quorum Sensing / drug effects*
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Ribosome Inactivating Proteins / pharmacology*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / physiopathology
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Staphylococcus / drug effects*
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Staphylococcus / growth & development
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Stents / adverse effects
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Surgical Wound Infection / drug therapy
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Surgical Wound Infection / metabolism
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Wound Healing / drug effects
Substances
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Anti-Infective Agents
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Hexoses
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Gallic Acid
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Ribosome Inactivating Proteins
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hamamelitannin