Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks

Int J Pharm. 2009 Feb 9;367(1-2):140-7. doi: 10.1016/j.ijpharm.2008.09.036. Epub 2008 Sep 30.

Abstract

Benznidazole (BZL) is one of the two therapeutic agents used for the treatment of Chagas' disease. However, the use of BZL in most pharmaceutical preparations and research experiments is still limited due to its low water solubility (0.4mg/mL). To overcome the dissolution rate-limiting step in oral absorption, chitosan microparticles prepared by the coacervation method were chosen, owing to non-toxicity of the polymer and mild conditions of the method. The influence of process parameters such as encapsulation efficiency, size, yield, and dissolution rate was optimized by using artificial neural networks (ANNs). The optimal conditions were found to be 1.5% (w/v) for the polymer concentration, 6.0% (w/v) for the coacervation agent concentration, 1400.0rpm for the stirring rate, and 5.0mL/min for the spraying rate. Confirmation experiments showed good agreement between predicted and experimental values of the optimized properties. These results indicate that ANNs is a valuable tool for the development of optimized BZL chitosan microparticles. To our knowledge it is the first report based on the development of optimized BZL microparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Chagas Disease / drug therapy*
  • Chitosan / chemistry*
  • Drug Carriers / chemistry*
  • Drug Compounding
  • Drug Design*
  • Humans
  • Microscopy, Electron, Scanning
  • Molecular Structure
  • Neural Networks, Computer*
  • Nitroimidazoles / administration & dosage
  • Nitroimidazoles / chemistry*
  • Nitroimidazoles / pharmacokinetics
  • Nitroimidazoles / therapeutic use
  • Particle Size
  • Solubility
  • Surface Properties
  • Trypanocidal Agents / administration & dosage
  • Trypanocidal Agents / chemistry*
  • Trypanocidal Agents / pharmacokinetics
  • Trypanocidal Agents / therapeutic use

Substances

  • Drug Carriers
  • Nitroimidazoles
  • Trypanocidal Agents
  • Chitosan
  • benzonidazole