Abstract
The antioxidant activity in vitro of three poly(phenylacetyloxy)-substituted 1,1':4',1"-terphenyl compounds from the edible mushroom Thelephora ganbajun were investigated. The IC50 values of compounds 1-3 for lipid peroxidation in rat liver homogenate were 400, 48, 54 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 values of 182, 74, 204 microM. They were also assessed on the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity with EC50 values of 49, 1233, 55 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Basidiomycota / chemistry*
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Biphenyl Compounds / pharmacology
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China
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HeLa Cells / drug effects
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Humans
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Hydrazines / pharmacology
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KB Cells / drug effects
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Lipid Peroxidation / drug effects*
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Liver / enzymology
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Male
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Picrates
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Rats
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Rats, Sprague-Dawley
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Superoxide Dismutase / drug effects
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Superoxide Dismutase / metabolism
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Terphenyl Compounds / isolation & purification
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Terphenyl Compounds / pharmacology*
Substances
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Antioxidants
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Biphenyl Compounds
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Hydrazines
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Picrates
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Terphenyl Compounds
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1,1-diphenyl-2-picrylhydrazyl
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Superoxide Dismutase