Abstract
Indian Leishmania donovani isolates (n = 19) from regional zones representing various levels of antimony resistance displayed significantly (P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology*
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Amphotericin B / therapeutic use
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Animals
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Antimony Sodium Gluconate / pharmacology*
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Antimony Sodium Gluconate / therapeutic use
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Antiprotozoal Agents / pharmacology*
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Antiprotozoal Agents / therapeutic use
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DNA Primers
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Drug Resistance
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Humans
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India / epidemiology
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Leishmania donovani / drug effects*
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Leishmania donovani / genetics
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Leishmaniasis, Visceral / drug therapy*
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Leishmaniasis, Visceral / parasitology
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Phosphorylcholine / analogs & derivatives*
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Phosphorylcholine / pharmacology
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Phosphorylcholine / therapeutic use
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Antiprotozoal Agents
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DNA Primers
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Phosphorylcholine
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miltefosine
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Amphotericin B
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Antimony Sodium Gluconate