Abstract
A secoiridoid aglycone with an atypical skeleton, named fagraldehyde (1), together with several known secoiridoids (gentiopicroside (2), sweroside (3), and swertiamarin (4)) were isolated from the bark and leaves of Fagraea fragrans collected in Cambodia. The conformations of 1 were evaluated on the basis of molecular modeling and NOESY correlations. A hypothetical biogenesis of fagraldehyde was proposed to explain the unusual skeleton. Compound 1 was weakly active in vitro against Plasmodium falciparum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cambodia
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Glucosides / chemistry
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Glucosides / isolation & purification
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Iridoid Glucosides
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology
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L-Lactate Dehydrogenase / analysis
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Plant Bark / chemistry
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Plant Leaves / chemistry
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Plants, Medicinal
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Plasmodium falciparum / drug effects*
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Pyrones / chemistry
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Pyrones / isolation & purification
Substances
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Glucosides
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Iridoid Glucosides
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Iridoids
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Pyrones
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fagraldehyde
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gentiopicroside
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swertiamarin
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L-Lactate Dehydrogenase
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sweroside