Voltage-sensing phosphatase: actions and potentials

Yasushi Okamura; Yoshimichi Murata; Hirohide Iwasaki

doi:10.1113/jphysiol.2008.163097

Voltage-sensing phosphatase: actions and potentials

J Physiol. 2009 Feb 1;587(3):513-20. doi: 10.1113/jphysiol.2008.163097. Epub 2008 Dec 15.

Authors

Yasushi Okamura¹, Yoshimichi Murata, Hirohide Iwasaki

Affiliation

¹ Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, Japan. yokamura@phys2.med.osaka-u.ac.jp

Abstract

Voltage sensors have been well studied in voltage-gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.

Publication types

Review

MeSH terms

Animals
Enzyme Activation
Humans
Ion Channel Gating / physiology
Ion Channels / chemistry
Ion Channels / metabolism
Membrane Potentials
Neurons / enzymology
Neurons / physiology*
PTEN Phosphohydrolase / chemistry
PTEN Phosphohydrolase / metabolism
Phosphatidylinositol Phosphates / metabolism
Phosphoric Monoester Hydrolases / physiology*
Phosphotransferases (Alcohol Group Acceptor) / metabolism
Protein Structure, Tertiary / physiology

Substances

Ion Channels
Phosphatidylinositol Phosphates
phosphatidylinositol 3,4,5-triphosphate
Phosphotransferases (Alcohol Group Acceptor)
phosphatidylinositol 4,5-biphosphate kinase
voltage-sensor-containing phosphatase, Ciona intestinalis
Phosphoric Monoester Hydrolases
PTEN Phosphohydrolase