Abstract
A novel antibiotic, GE2270 A, was isolated from the fermentation broth of a strain of Planobispora rosea. The product was found to inhibit bacterial protein synthesis. Structural characteristics showed similarities between GE2270 A and thiazolyl peptides such as micrococcin which is known to inhibit protein synthesis by acting directly on the ribosome. Despite this similarity GE2270 A showed functional analogy to kirromycin-like antibiotics and pulvomycin, as its molecular target was found to be elongation factor Tu (EF-Tu). GE2270 A is active against Gram-positive microorganism and anaerobes and differs from the other EF-Tu inhibitors in its spectrum of antimicrobial activity.
MeSH terms
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Actinomycetales / classification
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Actinomycetales / cytology
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Actinomycetales / physiology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteria, Anaerobic / drug effects*
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Bacteria, Anaerobic / metabolism
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Bacterial Proteins / biosynthesis*
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Bacteroides fragilis / drug effects
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / metabolism
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Moraxella catarrhalis / drug effects
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Mycobacterium tuberculosis / drug effects
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Peptides / chemistry
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Peptides / pharmacology
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Peptides / therapeutic use
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacology
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Peptides, Cyclic / therapeutic use
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Propionibacterium acnes / drug effects
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Protein Synthesis Inhibitors / chemistry
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Protein Synthesis Inhibitors / pharmacology*
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Protein Synthesis Inhibitors / therapeutic use
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Staphylococcal Infections / drug therapy
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Thiazoles / therapeutic use
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Peptides
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Peptides, Cyclic
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Protein Synthesis Inhibitors
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Thiazoles
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GE 2270 A