Probing the lactose.GM3 carbohydrate-carbohydrate interaction with glycodendrimers

Nicole Seah; Paul V Santacroce; Amit Basu

doi:10.1021/ol802613r

Probing the lactose.GM3 carbohydrate-carbohydrate interaction with glycodendrimers

Org Lett. 2009 Feb 5;11(3):559-62. doi: 10.1021/ol802613r.

Authors

Nicole Seah¹, Paul V Santacroce, Amit Basu

Affiliation

¹ Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.

PMID: 19123846
DOI: 10.1021/ol802613r

Abstract

Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate-carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Carbohydrates / chemistry*
Dendrimers / chemistry*
G(M3) Ganglioside / chemistry*
Glycoconjugates / chemical synthesis*
Glycoconjugates / chemistry
Lactose / chemistry*
Molecular Structure

Substances

Carbohydrates
Dendrimers
G(M3) Ganglioside
Glycoconjugates
Lactose