A lysine walk to high relaxivity collagen-targeted MRI contrast agents

Chem Commun (Camb). 2009 Jan 28:(4):430-2. doi: 10.1039/b819098d. Epub 2008 Dec 10.

Abstract

A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.

MeSH terms

  • Amino Acid Sequence
  • Chromatography, High Pressure Liquid
  • Collagen / metabolism*
  • Contrast Media / chemical synthesis*
  • Gadolinium DTPA / chemistry
  • Lysine / chemistry*
  • Magnetic Resonance Imaging*
  • Molecular Sequence Data
  • Structure-Activity Relationship

Substances

  • Contrast Media
  • Collagen
  • Gadolinium DTPA
  • Lysine