Hedgehog signaling: is Smo a G protein-coupled receptor?

Curr Biol. 2009 Feb 10;19(3):R125-7. doi: 10.1016/j.cub.2008.12.010.

Abstract

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.

Publication types

  • Review

MeSH terms

  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Hedgehog Proteins / metabolism*
  • Models, Biological
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction / physiology*
  • Smoothened Receptor

Substances

  • Drosophila Proteins
  • Hedgehog Proteins
  • Receptors, G-Protein-Coupled
  • Smoothened Receptor
  • smo protein, Drosophila