Abstract
The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.
MeSH terms
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Hedgehog Proteins / metabolism*
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Models, Biological
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism*
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Signal Transduction / physiology*
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Smoothened Receptor
Substances
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Drosophila Proteins
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Hedgehog Proteins
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Receptors, G-Protein-Coupled
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Smoothened Receptor
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smo protein, Drosophila