Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-

Christophe Decroos; Yun Li; Gildas Bertho; Yves Frapart; Daniel Mansuy; Jean-Luc Boucher

doi:10.1039/b819259f

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-

Chem Commun (Camb). 2009 Mar 21:(11):1416-8. doi: 10.1039/b819259f. Epub 2009 Jan 22.

Authors

Christophe Decroos¹, Yun Li, Gildas Bertho, Yves Frapart, Daniel Mansuy, Jean-Luc Boucher

Affiliation

¹ Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, CNRS UMR 8601, 45 rue des Saints Pères, 75006 Paris, France.

PMID: 19259606
DOI: 10.1039/b819259f

Abstract

Tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes are very efficiently oxidized by superoxide and alkylperoxyl radicals with selective formation of quinone-methide products; this should explain the previously reported specific measurement of O2*- using these EPR probes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carboxylic Acids / chemistry*
Electron Spin Resonance Spectroscopy
Free Radicals*
Heterocyclic Compounds, 3-Ring / chemistry*
Indolequinones / chemistry
Molecular Probes / chemistry*
Molecular Structure
Oxidation-Reduction
Oxygen / chemistry*

Substances

Carboxylic Acids
Free Radicals
Heterocyclic Compounds, 3-Ring
Indolequinones
Molecular Probes
quinone methide
Oxygen