Micropeptins from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100)

Takaya Kisugi; Tatsufumi Okino

doi:10.1021/np800631t

Micropeptins from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100)

J Nat Prod. 2009 Apr;72(4):777-81. doi: 10.1021/np800631t.

Authors

Takaya Kisugi¹, Tatsufumi Okino

Affiliation

¹ Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.

PMID: 19260658
DOI: 10.1021/np800631t

Abstract

Micropeptins C (1), D (2), E (3), and F (4) have been isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-100). The structures were elucidated by analyses of MS, NMR spectra, and chemical degradation. Micropeptins C, D, E, and F inhibited chymotrypsin with IC(50)'s of 1.1, 1.2, 1.0, and 1.5 microg/mL, respectively.

MeSH terms

Chymotrypsin / antagonists & inhibitors*
Depsipeptides / chemistry
Depsipeptides / isolation & purification*
Depsipeptides / pharmacology
Fresh Water
Inhibitory Concentration 50
Microcystis / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Depsipeptides
Chymotrypsin