Obstructive sleep apnea among obese patients with type 2 diabetes

Diabetes Care. 2009 Jun;32(6):1017-9. doi: 10.2337/dc08-1776. Epub 2009 Mar 11.

Abstract

Objective: To assess the risk factors for the presence and severity of obstructive sleep apnea (OSA) among obese patients with type 2 diabetes.

Research design and methods: Unattended polysomnography was performed in 306 participants.

Results: Over 86% of participants had OSA with an apnea-hypopnea index (AHI) >or=5 events/h. The mean AHI was 20.5 +/- 16.8 events/h. A total of 30.5% of the participants had moderate OSA (15 <or= AHI <30), and 22.6% had severe OSA (AHI >or=30). Waist circumference (odds ratio 1.1; 95% CI 1.0-1.1; P = 0.03) was significantly related to the presence of OSA. Severe OSA was most likely in individuals with a higher BMI (odds ratio 1.1; 95% CI 1.0-1.2; P = 0.03).

Conclusions: Physicians should be particularly cognizant of the likelihood of OSA in obese patients with type 2 diabetes, especially among individuals with higher waist circumference and BMI.

Trial registration: ClinicalTrials.gov NCT00194259.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Body Height
  • Body Weight
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Likelihood Functions
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / epidemiology
  • Oxygen Consumption
  • Polysomnography
  • Respiration Disorders / classification
  • Respiration Disorders / epidemiology
  • Respiration Disorders / physiopathology
  • Risk Factors
  • Severity of Illness Index
  • Sleep Apnea, Obstructive / complications
  • Sleep Apnea, Obstructive / epidemiology*
  • Sleep Apnea, Obstructive / physiopathology
  • Sleep, REM / physiology
  • Waist Circumference

Substances

  • Glycated Hemoglobin A

Associated data

  • ClinicalTrials.gov/NCT00194259