Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia

Dragan Milićević; Verica Jurić; Srđan Stefanović; Milijan Jovanović; Saša Janković

doi:10.3390/ijms9112169

Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia

Int J Mol Sci. 2008 Nov;9(11):2169-2183. doi: 10.3390/ijms9112169. Epub 2008 Nov 7.

Authors

Dragan Milićević¹, Verica Jurić², Srđan Stefanović¹, Milijan Jovanović³, Saša Janković¹

Affiliations

¹ Institute of Meat Hygiene and Technology, Kaćanskog 13, 11000 Belgrade, Serbia.
² Department for Animal Sciences, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 10, 21000 Novi Sad, Serbia.
³ Department of Pathomorphology, Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Beograd, Serbia.

Abstract

Samples of blood, kidney and liver were randomly selected from slaughtered pigs (n=90) and analyzed for ochratoxin A by HPLC. In addition, in order to obtain information on the occurrence of nephropathy, histological examinations were carried out. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g. The incidence of OTA in serum and kidney were very similar (31%, 33.3%), with a maximum concentration of 220.8 ng/mL, and 52.5 ng/g, respectively. Histopathological examination of kidneys confirmed tubulopathies with edema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules' cells were found.

Keywords: Ochratoxin A; nephropathy; pig; tissues.