Abstract
A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Ligands
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Peptoids / chemical synthesis
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Peptoids / chemistry*
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Protein Array Analysis*
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Proteins / chemistry*
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Proteins / isolation & purification
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Proteins / metabolism
Substances
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Ligands
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Peptoids
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Proteins