Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties

K Takesako; K Ikai; F Haruna; M Endo; K Shimanaka; E Sono; T Nakamura; I Kato; H Yamaguchi

doi:10.7164/antibiotics.44.919

Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties

J Antibiot (Tokyo). 1991 Sep;44(9):919-24. doi: 10.7164/antibiotics.44.919.

Authors

K Takesako¹, K Ikai, F Haruna, M Endo, K Shimanaka, E Sono, T Nakamura, I Kato, H Yamaguchi

Affiliation

¹ Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.

PMID: 1938613
DOI: 10.7164/antibiotics.44.919

Abstract

Aureobasidins A to R were isolated from the fermentation broth of Aureobasidium pullulans R106. Aureobasidins are cyclic depsipeptide antibiotics with MW's ranging from 1.070 to 1,148. Aureobasidins showed high in vitro antifungal activity against Candida albicans.

MeSH terms

Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Candida albicans / drug effects
Chemical Phenomena
Chemistry
Fermentation
Microbial Sensitivity Tests
Mitosporic Fungi / chemistry*

Substances

Antifungal Agents