A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes

Dalip Kumar; V Buchi Reddy; Shashwat Sharad; Urvashi Dube; Suman Kapur

doi:10.1016/j.ejmech.2009.04.017

A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes

Eur J Med Chem. 2009 Sep;44(9):3805-9. doi: 10.1016/j.ejmech.2009.04.017. Epub 2009 Apr 16.

Authors

Dalip Kumar¹, V Buchi Reddy, Shashwat Sharad, Urvashi Dube, Suman Kapur

Affiliation

¹ Chemistry Group, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India. dalipk@bits-pilani.ac.in

PMID: 19419801
DOI: 10.1016/j.ejmech.2009.04.017

Abstract

A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide was reused and recycled without any loss of activity and product yield. All the synthesized compounds were screened for in vitro antibacterial activity, and compounds 3a, 3b, 3f, 4b, 4c, 4d, 4e and 4g showed complete inhibition of bacterial growth at 128 microg/mL or less and the rest of the compounds exhibited incomplete inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Benzopyrans / chemical synthesis*
Benzopyrans / chemistry
Benzopyrans / pharmacology*
Catalysis
Escherichia coli / drug effects
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects
Pseudomonas putida / drug effects
Pyrans / chemical synthesis*
Pyrans / chemistry
Pyrans / pharmacology*
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Benzopyrans
Pyrans