Synthesis and structure-activity relationships of bengazole A analogs

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2928-30. doi: 10.1016/j.bmcl.2009.04.069. Epub 2009 Apr 22.

Abstract

Analogs of the potent antifungal agent, bengazole A, were prepared and evaluated against Candida spp. in both microbroth dilution and disk diffusion assays.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology
  • Candida / drug effects
  • Disk Diffusion Antimicrobial Tests
  • Oxazoles / chemical synthesis
  • Oxazoles / chemistry*
  • Oxazoles / pharmacology
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Oxazoles
  • bengazole A