Abstract
The two antimicrobial resorcinols malabaricone B [1] and malabaricone C [2] were isolated from mace, the dried seed covers of Myristica fragrans. Both compounds exhibited strong antifungal and antibacterial activities. Structure modifications by methylation or reduction resulted in diminished activity.
MeSH terms
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Anti-Infective Agents* / chemistry
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Anti-Infective Agents* / isolation & purification
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Microbial Sensitivity Tests
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Plants, Medicinal*
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Resorcinols / chemistry
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Resorcinols / isolation & purification
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Resorcinols / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Infective Agents
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Antifungal Agents
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Resorcinols
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malabaricone B
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malabaricone C