Photoactivable bioluminescent probes for imaging luciferase activity

Chem Commun (Camb). 2009 Jul 21:(27):4028-30. doi: 10.1039/b908346d. Epub 2009 Jun 9.

Abstract

A set of stable and efficient photoactivable bioluminescent probes for imaging luciferase activity has been developed, which displayed robust bioluminescent signals upon brief UV illumination in buffer, cells and living animals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Firefly Luciferin / analogs & derivatives*
  • Firefly Luciferin / chemical synthesis*
  • Firefly Luciferin / chemistry
  • Genes, Reporter
  • Luciferases, Firefly / genetics
  • Luciferases, Firefly / metabolism*
  • Luminescent Agents / chemical synthesis*
  • Luminescent Agents / chemistry
  • Luminescent Measurements
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Neoplasms / pathology
  • Ultraviolet Rays*

Substances

  • Luminescent Agents
  • Firefly Luciferin
  • Luciferases, Firefly