Abstract
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antibodies, Monoclonal / pharmacology*
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Antibodies, Monoclonal / therapeutic use
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Brain Neoplasms / drug therapy*
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Catalysis
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Hydroquinones / chemistry
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Hydroquinones / pharmacology*
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Materials Testing
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Models, Biological
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Nanoparticles / chemistry*
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Nanotechnology
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Particle Size
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Photochemistry
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Surface Properties
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Titanium / chemistry
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Titanium / pharmacology*
Substances
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Antibodies, Monoclonal
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Hydroquinones
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titanium dioxide
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Titanium