Abstract
Retinoic acid was thought to play a key instructive role during limb bud initiation and subsequent patterning. New results argue instead that its role is permissive: retinoic acid is essential only to antagonize early axial Fgf signals that otherwise inhibit the limb field.
MeSH terms
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Animals
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Body Patterning / physiology*
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Extremities / embryology*
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Fibroblast Growth Factors / antagonists & inhibitors
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Fibroblast Growth Factors / metabolism
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Gene Expression Regulation, Developmental / physiology*
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Models, Biological*
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Signal Transduction / physiology*
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Tretinoin / metabolism*
Substances
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Tretinoin
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Fibroblast Growth Factors