Abstract
Seven new polyoxygenated cembranoids possessing an alpha-methylene-gamma-lactone group, crassocolides G-M (1-7, resp.), have been isolated from the AcOEt extract of the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-7 were established by detailed spectroscopic analyses, including 2D-NMR spectroscopy ((1)H,(1)H-COSY, HMQC, HMBC, and NOESY), while the absolute configuration of 1 was determined using a modified reaction of Mosher's method. The cytotoxicity of compounds 1-7 against a limited panel of cancer cell lines was also determined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents / pharmacology
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antineoplastic Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Lactones