Animal models reveal role for tau phosphorylation in human disease

Jürgen Götz; Amadeus Gladbach; Luis Pennanen; Janet van Eersel; Andreas Schild; Della David; Lars M Ittner

doi:10.1016/j.bbadis.2009.09.008

Animal models reveal role for tau phosphorylation in human disease

Biochim Biophys Acta. 2010 Oct;1802(10):860-71. doi: 10.1016/j.bbadis.2009.09.008. Epub 2009 Sep 12.

Authors

Jürgen Götz¹, Amadeus Gladbach, Luis Pennanen, Janet van Eersel, Andreas Schild, Della David, Lars M Ittner

Affiliation

¹ Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia. jgoetz@med.usyd.edu.au

PMID: 19751831
DOI: 10.1016/j.bbadis.2009.09.008

Abstract

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / metabolism*
Alzheimer Disease / pathology
Animals
Disease Models, Animal*
Humans
Mice
Phosphorylation
tau Proteins / physiology*

Substances

tau Proteins