Abstract
The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H(2)O(2). Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H(2)O(2)-induced neurotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival
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Cells, Cultured
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Cerebellar Cortex / chemistry*
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Cerebellar Cortex / drug effects
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / pharmacology*
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Oxidative Stress / drug effects*
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Paeonia / chemistry*
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots / chemistry
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Rats
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Rats, Sprague-Dawley
Substances
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Neuroprotective Agents
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Plant Extracts