Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Angew Chem Int Ed Engl. 2009;48(48):9176-9. doi: 10.1002/anie.200903407.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii / enzymology*
  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology
  • Catalytic Domain
  • Enzyme Activation / drug effects
  • Models, Molecular
  • Nicotinamidase / chemistry*
  • Nicotinamidase / metabolism
  • Protein Structure, Tertiary
  • Pyrazinamide / chemistry*
  • Pyrazinamide / pharmacology
  • Substrate Specificity

Substances

  • Antitubercular Agents
  • Pyrazinamide
  • Nicotinamidase