CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IV. THE SYNTHESIS OF THEp-AMINOBENZYL ETHER OF THE SOLUBLE SPECIFIC SUBSTANCE OF TYPE III PNEUMOCOCCUS AND ITS COUPLING WITH PROTEIN

W F Goebel; O T Avery

doi:10.1084/jem.54.3.431

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IV. THE SYNTHESIS OF THEp-AMINOBENZYL ETHER OF THE SOLUBLE SPECIFIC SUBSTANCE OF TYPE III PNEUMOCOCCUS AND ITS COUPLING WITH PROTEIN

J Exp Med. 1931 Jul 31;54(3):431-6. doi: 10.1084/jem.54.3.431.

Authors

W F Goebel¹, O T Avery

Affiliation

¹ Hospital of The Rockefeller Institute for Medical Research.

Abstract

1. The p-amino and p-nitromonobenzyl ethers of the specific polysaccharide of Type III Pneumococcus have been prepared. 2. The diazonium ether of the specific polysaccharide has been coupled with serum globulin to yield a specific polysaccharide-protein complex and this complex has been used for immunization. The results of the immunological studies are presented in the following paper.